Indian Institute of Technology Delhi (IIT-D) has developed a handheld system for “early and rapid” detection of dengue. The system supplies outcomes inside the hour.
The venture’s Principal Investigator, Professor JP Singh of the Physics division, mentioned, “This ultrasensitive and handy device has a wide range of applications in the early-stage on-site detection of viral diseases and can produce the final report of investigation within an hour.”
“Conventional diagnostic tools like nucleic acid detection using Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) are a time taking process and it also requires expensive equipment and reagents for the diagnosis of dengue. These types of common diseases require a rapid, scalable and point-of-care diagnosis to be implemented at the community level and to reduce the workload of healthcare professionals,” IIT-D mentioned in an announcement.
“Understanding this, the GLancing Angle Deposition (GLAD) research group at IIT Delhi’s Physics Department has developed a handheld Surface Enhanced Raman Spectroscopy (SERS) based platform for early diagnosis of dengue virus,” it mentioned.
The institute mentioned the system had been “successfully tested” on scientific blood samples collected from lots of of individuals in collaboration with the National Institute of Malaria Research (NIMR).
In the GLAD approach, “only two micro-litres of a diluted serum was dropcasted on the SERS substrates and Raman spectra were collected by flashing 785 nm laser beam through the device”.
“All the data were fed in a statistical tool principal component analyser (PCA) software. The integrated device was able to clearly differentiate the three sets of blood samples; dengue positive, negative, and healthy. This method provides a sensitive, rapid, and field-deployable diagnosis of dengue at the early stage,” IIT-D mentioned.
The analysis work was funded by the IMPRINT India program of the Ministry of Education with New Age Instruments and Materials Pvt Ltd because the trade accomplice. The analysis was revealed within the January 2020 subject of the journal Analytical Chemistry.